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Lortab is a prescription medication that combines two active ingredients: hydrocodone and acetaminophen. It is primarily used for the management of moderate to severe pain. Hydrocodone is an opioid analgesic, which means it works by altering the way the brain and nervous system respond to pain. Acetaminophen, a non-opioid analgesic, enhances the effects of hydrocodone and helps to relieve pain as well as reduce fever.